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[Evaluation of the effectiveness of influenza trivalent polymer subunit vaccine "Grippol"]
G A El'shina1, M A Gorbunov, V I Shervarli
1Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, State Scientific Centre of the Research Institute of Immunology, Moscow, Russia.
Abstract:
Influenza polymer-subunit vaccine "Grippol", made up of the sterile conjugate of surface proteins of influenza viruses, groups A and B, with polyoxidonium (copolymer), was obtained at the State Scientific Centre of Research Institute of Immunology. As the result of our investigations, the coefficient of prophylactic effectiveness of vaccine "Grippol" was found to be 71%; in the presence of the 50% immune stratum in the group the coefficient of antiepidemic protection was found to be 66.4%. At the same time, cases of influenza and acute respiratory diseases were shown to take a milder form in persons immunized with vaccine "Grippol" than in the group of nonimmunized subjects. The results of this investigation did not show any side effects caused by the vaccine.