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Related Experiment Videos

Iron and zinc interactions in humans

P Whittaker1

  • 1Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. pvw@cfsan.fda.gov

The American Journal of Clinical Nutrition
|August 13, 1998
PubMed
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High iron intake can hinder zinc absorption, but this is not observed when consumed with meals. Fortifying foods with iron at current levels does not negatively impact zinc absorption.

Area of Science:

  • Nutrition Science
  • Public Health
  • Food Science

Background:

  • Iron deficiency is the world's most common nutritional deficiency.
  • Zinc deficiency impacts growth, development, and immune function, particularly in developing nations.
  • Food fortification and supplements are strategies to increase iron and zinc intake.

Purpose of the Study:

  • To review the impact of iron on zinc absorption.
  • To evaluate the effects of iron fortification on zinc absorption in meals.
  • To discuss the safety and usage trends of iron and zinc compounds in food.

Main Methods:

  • Literature review of studies on iron and zinc absorption.
  • Analysis of postulations regarding the effect of ionic species on zinc absorption.

Related Experiment Videos

  • Examination of trends in the use of zinc salts and iron sources for food fortification.

    • Main Results:

    • High iron concentrations negatively affect zinc absorption in solution, but not when consumed with meals.
    • A total dose of >25 mg iron may measurably affect zinc absorption, suggesting between-meal supplementation.
    • Recent stable isotope studies indicate current iron fortification levels do not adversely affect zinc absorption.

    Conclusions:

    • Iron and zinc interactions are crucial for nutritional interventions.
    • Food fortification with iron at current levels is a safe strategy for zinc absorption.
    • Trends show increased use of zinc oxide, zinc sulfate, elemental iron, and ferrous fumarate in food.