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Epilepsy in patients with multiple sclerosis: radiological-clinical correlations
T Moreau1, D Sochurkova, M Lemesle
1Neurophysiological Laboratory, Hôpital Croix Rousse, Lyon, France.
Purpose:
To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS).
Methods:
Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population.
Results:
In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs).
Conclusions:
Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.