Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of oxygen consumption in the dog liver during temporary arterial occlusion

M Andreen, L Irestedt

    Acta Physiologica Scandinavica
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Strong ion and weak acid analysis in severe preeclampsia.

    British journal of anaesthesia·2017
    Same author

    Chronic adhesive arachnoiditis after repeat epidural blood patch.

    International journal of obstetric anesthesia·2015
    Same author

    Auditory function following post-dural puncture headache treated with epidural blood patch. A long-term follow-up.

    Acta anaesthesiologica Scandinavica·2015
    Same author

    Management of accidental dural puncture and post-dural puncture headache after labour: a Nordic survey.

    Acta anaesthesiologica Scandinavica·2010
    Same author

    The definition of hypotension affects its incidence.

    Acta anaesthesiologica Scandinavica·2010
    Same author

    Water intoxication following labour and surgery: blaming oxytocin--the easy way out?

    Acta anaesthesiologica Scandinavica·2009

    Occluding the hepatic artery significantly reduced liver oxygen consumption by 36% in dogs. Whole body and portal-drained tissue oxygen uptake remained stable, indicating liver oxygen uptake is sensitive to oxygen tension.

    Area of Science:

    • Physiology
    • Gastroenterology
    • Splanchnic Circulation

    Background:

    • The hepatic artery is a major source of oxygen for the liver.
    • Understanding the liver's oxygen consumption is crucial for assessing its metabolic state.
    • The contribution of the hepatic artery to liver oxygen supply varies.

    Purpose of the Study:

    • To investigate the impact of hepatic artery occlusion on liver and splanchnic oxygen consumption.
    • To determine the role of the hepatic artery in supplying oxygen to the liver.
    • To explore the relationship between oxygen tension and liver oxygen uptake.

    Main Methods:

    • Anesthetized dogs were used to model hepatic artery occlusion.
    • Measurements included whole body, liver, and portal-drained tissue oxygen consumption.

    Related Experiment Videos

  • Hepatic artery occlusion was maintained for 45 minutes.

    • Main Results:

    • Liver oxygen uptake decreased to 64% of control values during hepatic artery occlusion.
    • Hepatic artery occlusion did not significantly alter whole body or portal-drained tissue oxygen consumption.
    • Oxygen extraction from portal blood showed a slight increase.
    • Liver oxygen consumption returned to baseline levels 45 minutes after reperfusion.

    Conclusions:

    • Liver oxygen uptake is significantly influenced by hepatic artery blood flow.
    • Oxygen tension in the liver appears to be a key regulator of its oxygen consumption.
    • The liver can compensate for reduced arterial oxygen supply through increased portal venous oxygen extraction, but this is limited.