Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin pulsatility in obese and normal prepubertal children

G Radetti1, L Ghizzoni, C Paganini

  • 1Department of Pediatrics, Regional Hospital of Bolzano, Italy.

Hormone Research
|August 14, 1998
PubMed
Summary

Insulin secretion in prepubertal children is pulsatile, similar to adults. Higher body weight in obese children is linked to altered insulin secretion patterns, which may normalize with weight reduction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Mediating Role of Emotion Dysregulation in the Association Between Perfectionism and Eating Psychopathology Symptoms.

Clinical psychology & psychotherapy·2024
Same author

Recovery of chronic motor neuropathy due to acute intermittent porphyria after givosiran treatment in a young boy: a case report.

European review for medical and pharmacological sciences·2024
Same author

The Metacognitions about Binge Eating Questionnaire: Investigation of the association between specific metacognitions and Binge Eating Disorder.

Clinical psychology & psychotherapy·2023
Same author

Correction to: A non-classical presentation of APECED in a family with heterozygous R203X AIRE gene mutation.

Journal of endocrinological investigation·2022
Same author

A non-classical presentation of APECED in a family with heterozygous R203X AIRE gene mutation.

Journal of endocrinological investigation·2022
Same author

Multicenter retro-prospective observational study on chronic hypoparathyroidism and rhPTH (1-84) treatment.

Journal of endocrinological investigation·2022

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Obesity Studies

Background:

  • Insulin secretion is known to be pulsatile in adults.
  • The pattern of insulin secretion in prepubertal children and its relationship with body weight require further investigation.

Purpose of the Study:

  • To determine if insulin secretion is pulsatile in prepubertal children.
  • To examine the influence of body weight on the pulsatile pattern of insulin secretion in this age group.

Main Methods:

  • Insulin profiles were measured using 4-minute sampling over 2 hours in fasted prepubertal obese children and healthy controls.
  • Obese children were re-evaluated after a weight reduction intervention.
  • Data analysis was performed using the Pulsar program to assess pulsatility parameters.

Related Experiment Videos

Main Results:

  • Obese children exhibited higher mean insulin levels and more frequent, larger amplitude insulin peaks compared to controls.
  • Weight reduction led to normalization of mean insulin levels and overall insulin secretion (AUC0), but did not significantly alter peak frequency, amplitude, or duration.
  • Body Mass Index Standard Deviation Score (BMI-SDS) strongly correlated with parameters of pulsatile insulin secretion.

Conclusions:

  • Insulin secretion in prepubertal children demonstrates a pulsatile pattern.
  • Body weight significantly influences the pattern of insulin secretion in children, with obesity associated with altered pulsatility.