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[Analysis of cytokine receptor function by gene manipulation]
1Department of Molecular Cell Biology, Tokyo Medical and Dental University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
Summary
Gene manipulation in mice revealed the in vivo roles of gp130, a shared signal transducer for cytokine receptors. Studies using deficient and activated gp130 mouse models illuminate cytokine signaling pathways.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Context:
- Cytokines play crucial roles in physiological and pathological processes.
- Cytokine signaling is characterized by functional pleiotropy and redundancy.
- Shared receptor components, like gp130, contribute to cytokine redundancy.
Purpose:
- To review studies utilizing gene manipulation techniques to investigate the in vivo roles of the signal transducer gp130.
- To examine mouse models with gp130 deficiency, constitutive activation, or dominant-negative forms.
- To synthesize findings from gp130-related receptor and ligand knockout mice.
Summary:
- Gene manipulation in mice has been instrumental in dissecting cytokine receptor functions.
- Mouse models deficient for gp130 or exhibiting altered gp130 signaling provide insights into its physiological and pathological roles.
- Analysis of these models, alongside studies on related receptors and ligands, elucidates the complex network of cytokine signaling.
Impact:
- Provides a comprehensive overview of gp130's in vivo functions through genetic manipulation studies.
- Highlights the importance of gp130 as a central mediator in various cytokine-driven biological processes.
- Offers valuable information for understanding cytokine-related diseases and developing targeted therapies.