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[Analysis of cytokine receptor function by gene manipulation]

T Taga1

  • 1Department of Molecular Cell Biology, Tokyo Medical and Dental University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
PubMed

Insights

Gene manipulation in mice revealed the in vivo roles of gp130, a shared signal transducer for cytokine receptors. Studies using deficient and activated gp130 mouse models illuminate cytokine signaling pathways.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Context:

  • Cytokines play crucial roles in physiological and pathological processes.
  • Cytokine signaling is characterized by functional pleiotropy and redundancy.
  • Shared receptor components, like gp130, contribute to cytokine redundancy.

Purpose:

  • To review studies utilizing gene manipulation techniques to investigate the in vivo roles of the signal transducer gp130.
  • To examine mouse models with gp130 deficiency, constitutive activation, or dominant-negative forms.
  • To synthesize findings from gp130-related receptor and ligand knockout mice.

Summary:

  • Gene manipulation in mice has been instrumental in dissecting cytokine receptor functions.
  • Mouse models deficient for gp130 or exhibiting altered gp130 signaling provide insights into its physiological and pathological roles.
  • Analysis of these models, alongside studies on related receptors and ligands, elucidates the complex network of cytokine signaling.

Impact:

  • Provides a comprehensive overview of gp130's in vivo functions through genetic manipulation studies.
  • Highlights the importance of gp130 as a central mediator in various cytokine-driven biological processes.
  • Offers valuable information for understanding cytokine-related diseases and developing targeted therapies.

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