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[Novel orphan receptor: ROR gamma expressed during adipocyte differentiation]
1Department of Medicine II, Osaka University Medical School.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
Summary
ROR gamma, a nuclear receptor, plays a key role in adipocyte differentiation. Its expression is regulated by PPAR gamma ligands and it interacts with Rev-ErbA, influencing fat cell development.
Area of Science:
- Molecular biology
- Endocrinology
- Cell biology
Background:
- The ROR/RZR nuclear orphan receptor family includes ROR alpha, beta, and gamma.
- ROR alpha's roles in cerebellum development and immune response are known.
- Limited information exists on ROR beta and ROR gamma functions.
Purpose of the Study:
- To investigate the role of ROR gamma in adipocyte differentiation.
- To explore the regulation of ROR gamma expression.
- To understand the interaction between ROR gamma and other nuclear receptors in adipogenesis.
Main Methods:
- Analysis of ROR gamma expression during adipocyte differentiation.
- Investigating the effect of PPAR gamma ligands and overexpression on ROR gamma.
- Studying the antagonistic relationship between Rev-ErbA and ROR gamma.
Main Results:
- ROR gamma expression is induced during the mid-stage of adipocyte differentiation.
- ROR gamma induction is enhanced by PPAR gamma ligands and overexpression.
- Rev-ErbA antagonizes ROR gamma's transcriptional activity on shared response elements.
Conclusions:
- ROR gamma is a significant factor in adipocyte differentiation.
- Cross-talk between ROR and Rev-Erb receptors likely regulates adipocyte-associated genes.
- Further research into ROR gamma's role in adipogenesis is warranted.