Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[IL-18 and IL-18 receptor]

S Kashiwamura1, H Okamura

  • 1Laboratory of Host Defenses, Hyogo College of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lateromedial gradient of the susceptibility of midbrain dopaminergic neurons to neonatal 6-hydroxydopamine toxicity.

Experimental neurology·1995
Same author

Neurotransmitters for the canine inferior pharyngeal constrictor muscle.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1995
Same author

p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells.

The Journal of biological chemistry·1995
Same author

Cloning of a new cytokine that induces IFN-gamma production by T cells.

Nature·1995
Same author

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock.

Infection and immunity·1995
Same author

Adenylyl cyclase activity in human decidua and myometrium during pregnancy and labour.

Journal of reproduction and fertility·1995

Interleukin-18 (IL-18), a cytokine from macrophages, influences immune responses by inducing IFN-gamma and enhancing NK cell activity. Further research is needed to understand its role in inflammatory and autoimmune diseases.

Area of Science:

  • Immunology
  • Molecular Biology

Context:

  • Interleukin-18 (IL-18), initially known as interferon-gamma inducing factor (IGIF), is a cytokine produced by activated macrophages.
  • Recent findings indicate IL-18's pleiotropic effects, including enhancing FasL expression, NK cell activity, and GM-CSF production.

Purpose:

  • To clone the murine Interleukin-18 receptor (IL-18R) cDNA.
  • To investigate the expression of IL-18R mRNA in T cells stimulated with IL-12.

Summary:

  • The murine IL-18R cDNA was successfully cloned using human IL-18R sequence via RT-PCR.
  • Northern blot analysis revealed significantly higher IL-18R mRNA levels in IL-12-stimulated T cells compared to non-stimulated cells.

Impact:

  • IL-18 is implicated in the pathogenesis of chronic inflammatory diseases such as endotoxin shock, hepatitis, and autoimmune diabetes.

Related Experiment Videos

  • Further studies are crucial to elucidate the physiological roles of IL-18 in diverse inflammatory and autoimmune conditions.