Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thyroid hormone receptors and the disorders]

T Nagaya1, H Seo

  • 1Department of Endocrinology and Metabolism, Nagoya University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
PubMed
Summary

Thyroid hormone receptors (TRs) regulate gene transcription. Analyzing TRs can uncover molecular mechanisms behind thyroid hormone resistance and other disorders, aiding diagnosis and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing Gluon Fluctuations in Nuclei with the First Energy-Dependent Measurement of Incoherent J/ψ Photoproduction in Ultraperipheral PbPb Collisions.

Physical review letters·2025
Same author

Measurement of WWZ and ZH Production Cross Sections at sqrt[s]=13 and 13.6 TeV.

Physical review letters·2025
Same author

Observation of the Charged-Particle Multiplicity Dependence of σ_{ψ(2S)}/σ_{J/ψ} in p-Pb Collisions at 8.16 TeV.

Physical review letters·2025
Same author

Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Physical review letters·2025
Same author

Positive Neutrino Masses with DESI DR2 via Matter Conversion to Dark Energy.

Physical review letters·2025
Same author

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2025

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Context:

  • Thyroid hormone is crucial for development and metabolism.
  • Thyroid hormone receptors (TRs) mediate hormone action by regulating gene transcription.
  • TRs function in a ligand-dependent manner.

Purpose:

  • To analyze the function of thyroid hormone receptors (TRs).
  • To elucidate the molecular mechanisms underlying TR-related disorders.
  • To explore potential diagnostic and therapeutic strategies for these conditions.

Summary:

  • Abnormalities in TR function are associated with disorders like resistance to thyroid hormone (RTH), malignancy, and euthyroid sick syndrome.
  • Mutant TRs have been identified as causative agents for RTH and certain cancers.
  • Functionally impaired TRs may also contribute to euthyroid sick syndrome.

Impact:

  • Understanding TRs can reveal the molecular basis of various endocrine and metabolic disorders.
  • This research may offer new insights for diagnosing and treating conditions linked to TR dysfunction.
  • Identifying the role of TRs in disease can pave the way for targeted therapies.

Related Experiment Videos