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[Endothelin receptor/physiological role]

Y Abe1, Y Kasuya

  • 1Department of Pharmacology, University of Tsukuba.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 14, 1998
PubMed
Summary
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Endothelin (ET) receptor subtypes and their signaling pathways are crucial for understanding physiological roles. Studies using ET receptor blockers and gene-targeting in mice have significantly advanced ET system research.

Area of Science:

  • Endocrinology and Pharmacology
  • Molecular Biology
  • Physiology

Context:

  • Endothelin (ET) system's physiological roles clarified over a decade.
  • Pharmacological, biochemical, and molecular biological methods advanced ET research.
  • ET receptor blockers and gene-targeting accelerate ET system investigations.

Purpose:

  • To introduce the structure of endothelin (ET) receptor subtypes.
  • To explain intracellular signal transduction pathways of ET receptors.
  • To discuss the physiological roles of ET receptor subtypes using data from ET receptor-deficient mice.

Summary:

  • The structure and intracellular signaling of endothelin (ET) receptor subtypes are detailed.
  • Investigations into the ET system have been accelerated by receptor blockers and gene-targeting approaches.

Related Experiment Videos

  • Physiological roles of ET receptor subtypes are discussed, referencing studies on ET receptor-deficient mice.

    • Impact:

    • Enhanced understanding of endothelin receptor subtypes and their signaling.
    • Provides insights into the physiological and pathophysiological roles of the ET system.
    • Highlights the utility of genetic and pharmacological tools in ET research.