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Published on: April 13, 2015
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma
1Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. g-li@ski.mskcc.org
Abstract:
We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70-/- mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4+CD8+ tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.
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