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Disopyramide in ventricular tachycardia

J Hulting, G Rosenhamer

    Acta Medica Scandinavica
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide phosphate effectively treated ventricular tachycardia in a patient unresponsive to other drugs. The antiarrhythmic medication showed minimal impact on hemodynamics and prevented recurrent episodes.

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    Area of Science:

    • Cardiology
    • Clinical Pharmacology

    Background:

    • Ventricular tachycardia (VT) poses a significant risk, especially when refractory to standard antiarrhythmic therapies.
    • Disopyramide phosphate (DE) is an antiarrhythmic drug with potential hemodynamic effects that require careful consideration.

    Observation:

    • Intravenous administration of disopyramide phosphate in divided doses to a patient with VT resulted in minimal changes to systemic arterial pressure (SAP), cardiac output (Q), stroke work (SW), and pulmonary artery diastolic pressure (PADP).
    • A notable decrease in heart rate from 123 to 103 beats/min was observed.
    • Successful reversion to sinus rhythm occurred at a serum concentration exceeding 4.3 mug/ml.

    Findings:

    • Following reversion to sinus rhythm, significant increases in cardiac output (Q) and stroke work (SW) were noted above baseline values.

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  • Pulmonary artery diastolic pressure (PADP) decreased substantially from 20 to 6 mmHg, while mean SAP remained relatively stable.
  • No adverse effects were apparent during or after drug administration.

    • Implications:

    • Disopyramide phosphate demonstrated efficacy in preventing recurrent VT attacks in a treatment-resistant patient.
    • Oral administration of 800 mg/day of disopyramide phosphate proved effective for long-term VT management.
    • The drug appears to have a favorable hemodynamic profile in this specific clinical context, warranting further investigation.