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Related Experiment Videos

The relationship between substance use disorders, impulse control disorders, and pathological aggression

K T Brady1, H Myrick, S McElroy

  • 1Medical University of South Carolina, Department of Psychiatry, Charleston 29425, USA.

The American Journal on Addictions
|August 14, 1998
PubMed
Summary

Substance use disorders, impulse control disorders, and pathological aggression are linked, potentially due to neurotransmitter system dysfunction. Treatments targeting these systems show promise for managing these complex conditions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Substance use disorders (SUDs), impulse control disorders (ICDs), and pathological aggression frequently co-occur.
  • Evidence suggests shared neurobiological underpinnings, including neurotransmitter system dysfunction, particularly involving serotonin and GABA.
  • Comorbidity data and treatment responses indicate a relationship between these conditions.

Purpose of the Study:

  • To examine the intricate relationship between substance use disorders, impulse control disorders, and pathological aggression.
  • To review the phenomenological, neurobiological, and comorbidity evidence linking these conditions.
  • To explore the therapeutic potential of pharmacotherapies targeting shared neurobiological pathways.

Main Methods:

Related Experiment Videos

  • Review of existing literature encompassing phenomenological, neurobiological, and comorbidity data.
  • Analysis of evidence from pharmacotherapy studies for aggression, impulse control, and substance use disorders.
  • Examination of the role of neurotransmitter systems, specifically serotonin and GABA.

    • Main Results:

    • Significant links exist between substance use, impulsivity, and pathological aggression.
    • Dysfunction in serotonin and GABAergic systems appears implicated in both SUDs and ICDs/aggression.
    • Serotonergic agents and mood-stabilizing anticonvulsants (with GABAergic activity) show preliminary therapeutic potential.

    Conclusions:

    • Neurotransmitter system dysfunction provides a potential unifying mechanism for SUDs, ICDs, and pathological aggression.
    • Pharmacological interventions targeting serotonergic and GABAergic systems warrant further investigation for these disorders.
    • These findings highlight the need for integrated treatment approaches for individuals with co-occurring SUDs, ICDs, and aggression.