[Changes in small-angle light scattering by platelets during their activation and aggregation]
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Updated: Oct 28, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
D I Roshchupkin1, V V Berzhitskaia, A Iu Sokolov
1Russian State Medical University, Moscow, Russia.
Abstract:
Small-angle light scattering (0.5-7 degrees) platelets is enhanced upon the adenosine-5'-diphosphate-induced formation of microaggregates of platelets. The intensity of the scattered light, measured within a short period of time after stimulation of platelets, may by used as a nephelometric quantitative index of their initial aggregation. The light transmittance of platelet suspensions decreases after stimulation due to both the rounding of cell body and the initial aggregation of cells. Sodium hypochlorite at concentrations corresponding to its content in tap water inhibits the Ca(2+)-induced aggregation of isolated rabbit platelets. The tap water causes the transition of platelets to a state that is refractory with respect to CaCl2.
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