Mitral valve replacement in sickle cell disease
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Updated: Oct 28, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
M T Sgambati1, N D Kon, J M Cruz
1Department of Internal Medicine/Hematology and Oncology, Bowman Gray School of Medicine, Winston-Salem, North Carolina, USA.
Abstract:
Cardiac dysfunction, including mitral valve regurgitation and congestive heart failure, can occur in patients with sickle cell disease. However, major surgery poses a greater risk in this population. This paper reports on the management of a patient with sickle cell disease who underwent successful replacement of the mitral valve.
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