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Related Experiment Videos

Changes in immune-endocrine response after surgery

H Yamauchi1, E Kobayashi, T Yoshida

  • 1Department of Surgery, Jichi Medical School, Tochigi, Japan.

Cytokine
|August 14, 1998
PubMed
Summary

Major surgery, like oesophagectomy, triggers significant hormonal and cytokine responses, impacting immune cells. Less invasive procedures show a quicker return to normal immune cell counts and inflammatory markers.

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Area of Science:

  • Surgical oncology
  • Immunology
  • Endocrinology

Background:

  • Surgical trauma elicits complex physiological responses, including hormonal and cytokine changes.
  • The impact of different surgical procedures on these responses requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between hormonal and cytokine profiles and immune cell responses following various surgical interventions.
  • To compare these responses across different surgical trauma extents.

Main Methods:

  • Patients undergoing thoracic oesophagectomy, pulmonary lobectomy, modified mastectomy, and laparoscopic cholecystectomy were analyzed.
  • Assays for circulating neutrophils, lymphocytes, adrenocorticotrophic hormone (ACTH), cortisol, antidiuretic hormone (ADH), and cytokines (TNF-alpha, IL-1 beta, IL-6, IL-10) were performed post-operatively.

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Main Results:

  • Major surgeries (oesophagectomy, lobectomy) showed prolonged neutrophilia and lymphocytopenia compared to less invasive procedures (mastectomy, cholecystectomy).
  • Interleukin-6 (IL-6) and Interleukin-10 (IL-10) levels increased significantly after major surgeries but not minor ones.
  • Hormonal patterns were consistent across all groups, while specific cytokine responses correlated with surgical trauma extent.

Conclusions:

  • The extent of surgical trauma significantly influences post-operative immune cell dynamics and specific cytokine profiles (IL-6, IL-10).
  • Major thoracic surgeries induce more pronounced and prolonged inflammatory and immune responses compared to abdominal or breast surgeries.