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Postexposure prophylaxis for human immunodeficiency virus: frequency of initiation and completion of newly
K A Sepkowitz1, P Rivera, J Louther
1St Clare's Hospital, New York City, New York, USA.
Abstract:
Recent evidence demonstrating the efficacy of zidovudine, as well as experience with protease inhibitors, led to revision of recommendations for occupational exposures to human immunodeficiency virus-infected blood. At our hospital, this resulted in significant increases in rates of reported exposures and prophylaxis initiation. Among 10 healthcare workers given three-drug, protease-inhibitor-containing regimens, five completed 4 weeks, two completed 4 weeks of two drugs, and three stopped due to intolerance. Three workers missed work due to side effects.
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