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HTLV-I associated primary CNS T-cell lymphoma
A G Marshall1, R Pawson, M Thom
1National Hospital for Neurology and Neurosurgery, London, UK.
Journal of the Neurological Sciences
|August 14, 1998
Summary
Primary central nervous system (CNS) Adult T-cell lymphoma/leukaemia (ATLL) is exceptionally rare. This case highlights a unique presentation of primary CNS ATLL in the brainstem, co-occurring with atypical Herpes simplex encephalitis.
Area of Science:
- Neurology
- Oncology
- Virology
Background:
- Primary central nervous system (CNS) lymphoma is rare, with T-cell types being exceptionally uncommon.
- Adult T-cell lymphoma/leukaemia (ATLL), associated with Human T-cell lymphoma virus type 1 (HTLV-1), frequently involves the CNS, but primary CNS disease is exceptional.
Observation:
- A unique case of primary CNS ATLL is presented, characterized by brainstem infiltration.
- The tumour exhibited an unusual co-occurrence with atypical Herpes simplex encephalitis.
- The distribution of the encephalitis mirrored the pattern of CNS tumour infiltration.
Findings:
- Clinicopathological and molecular data were utilized to characterize this rare primary CNS ATLL.
- The findings suggest a potential link or co-localization between ATLL and Herpes simplex virus in the CNS.
- This case expands the understanding of CNS involvement patterns in ATLL.
Implications:
- This case underscores the importance of considering rare presentations of ATLL in the CNS.
- Further research may elucidate the mechanisms underlying concurrent CNS ATLL and viral encephalitis.
- Understanding these rare CNS manifestations is crucial for accurate diagnosis and patient management.