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Plasma renin activity could be a useful predictor of left ventricular hypertrophy in essential hypertensives
1Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Insights
Plasma renin activity (PRA) may predict left ventricular hypertrophy (LVH) in untreated essential hypertension patients. This finding helps identify organ damage early in hypertension management.
Area of Science:
- Cardiology
- Nephrology
- Clinical Medicine
Background:
- Essential hypertension is a leading cause of cardiovascular disease.
- Left ventricular hypertrophy (LVH) is a key indicator of target organ damage in hypertension.
- Early identification of LVH is crucial for effective hypertension management.
Purpose of the Study:
- To determine the correlation between clinical and laboratory parameters and LVH in untreated essential hypertensives.
- To identify predictors of LVH at the initial clinic visit.
Main Methods:
- 108 untreated essential hypertensive patients (53 males, 55 females, avg. age 52 years) were studied.
- Electrocardiographic voltage (SV1 + R(V5, V6)) was used to determine LVH.
- Stepwise multiple regression analysis was employed to identify correlations.
Main Results:
- Electrocardiographic voltage correlated with blood pressure in both sexes.
- In patients with LVH, SV1 + R(V5, V6) correlated with plasma renin activity (PRA) in both sexes.
- Creatinine concentration (Cr) was also associated with LVH in males.
Conclusions:
- Plasma renin activity (PRA) may serve as a valuable predictor of left ventricular hypertrophy (LVH) in essential hypertension.
- These findings aid in the early detection of target organ damage in hypertensive patients.
- Integrating PRA measurement could enhance risk stratification in hypertension care.
Abstract:
To clarify the ability of clinical and laboratory parameters to reflect target organ damage, especially left ventricular hypertrophy (LVH), we investigated which of these parameters might correlate to LVH as determined by electrocardiographic voltage at the first clinic visit in 108 (53 males and 55 females, average age 52 +/- 10 years) untreated essential hypertensives. The sum of the amplitude of the S wave in lead V1 plus that of the R wave in lead V5 or V6 (SV1 + R(V5, V6)) was correlated with blood pressure in both males and females. In subjects with LVH (SV1 + R(V5, V6) > or = 3.5mV), a stepwise multiple regression analysis revealed that SV1 + R(V5, V6) was associated with plasma renin activity (PRA) in both males and females, and with creatinine concentration (Cr) in males. These results suggest that PRA at the first visit could be a useful predictor of LVH in patients with essential hypertension.