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Major glutamatergic projection from subplate into visual cortex during development

E M Finney1, J R Stone, C J Shatz

  • 1Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.

The Journal of Comparative Neurology
|August 14, 1998
PubMed
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Subplate neurons are crucial for forming thalamocortical connections. Our study shows many projecting subplate neurons are glutamatergic, potentially driving visual cortex development.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cortical Development

Background:

  • Subplate neurons are the earliest cortical neurons, vital for thalamocortical connection formation.
  • Ocular dominance columns in visual cortex layer 4 depend on these connections.

Purpose of the Study:

  • Identify neurotransmitters and peptides in subplate neurons projecting to visual cortex.
  • Investigate the role of subplate neurons in thalamocortical circuit development.

Main Methods:

  • Retrograde labeling using fluorescent microspheres in ferret visual cortex.
  • Immunostaining for glutamate, GAD-67, parvalbumin, NPY, SRIF, and NOS.

Main Results:

  • Cortically projecting subplate neurons are primarily located in the upper subplate.

Related Experiment Videos

  • Approximately 50% of these neurons are glutamatergic.
  • Most projecting neurons did not express GAD-67, parvalbumin, NPY, SRIF, or NOS.

    • Conclusions:

    • Subplate neurons provide significant glutamatergic input to the developing cortical plate.
    • This glutamatergic excitation may be essential for activity-dependent formation of ocular dominance columns.