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Photosensitive dermatitis caused by pyridoxine hydrochloride
1Department of Dermatology, Hyogo Medical Center for Adults, Akashi, Japan.
Journal of the American Academy of Dermatology
|August 14, 1998
Summary
Pyridoxine hydrochloride can cause photosensitivity reactions. This study details two cases of photoallergic reactions to pyridoxine hydrochloride, confirmed by photopatch testing and reduced minimal erythematous dose (MED) after UVA exposure.
Area of Science:
- Dermatology
- Photobiology
- Pharmacology
Background:
- Photosensitive reactions to pyridoxine hydrochloride are rare.
- Detailed photosensitivity studies in patients with pyridoxine-induced photosensitivity are lacking.
Observation:
- Two patients presented with photosensitivity attributed to pharmacologic doses of pyridoxine hydrochloride.
- Photopatch tests were positive for pyridoxine hydrochloride in both patients.
- UVA minimal erythematous dose (MED) decreased post-intravenous pyridoxine hydrochloride injection.
Findings:
- Both patients exhibited positive photopatch tests for pyridoxine hydrochloride.
- Reduced MED for UVA indicates increased photosensitivity after pyridoxine hydrochloride administration.
- Normal controls showed no reaction to pyridoxine hydrochloride or vitamin B complex containing it.
Implications:
- These findings suggest a photoallergic mechanism for pyridoxine hydrochloride-induced photosensitivity.
- Highlights the importance of considering pyridoxine hydrochloride in differential diagnosis of drug-induced photosensitivity.
- Further research into pyridoxine hydrochloride photosensitivity is warranted.