Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baroreceptor reflexes in human hypertension

G Mancia, J Ludbrook, A Ferrari

    Circulation Research
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic-pathological study.

    The British journal of dermatology·2004
    Same author

    On the conversion coefficients for cosmic ray dosimetry.

    Radiation protection dosimetry·2003
    Same author

    Preliminary studies on compatibility between high yield levels and the well-being of dairy cows.

    Veterinary research communications·2003
    Same author

    Advanced ovarian carcinoma: usefulness of [(18)F]FDG-PET in combination with CT for lesion detection after primary treatment.

    The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)·2003
    Same author

    Emerging problems in the pharmacology of migraine: interactions between triptans and drugs for prophylaxis.

    Pharmacological research·2003
    Same author

    Estimating mixed field effects: an application supporting the lack of a non-linear component for chromosome aberration induction by neutrons.

    Radiation protection dosimetry·2003
    Same journal

    SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

    Circulation research·2026
    Same journal

    Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

    Circulation research·2026
    Same journal

    Targeting Late Na<sup>+</sup> Current: Too Late or Better Late Than Never?

    Circulation research·2026
    Same journal

    HFpEF-Any: Human Single-Nuclear Transcriptomics Challenging the Translational Validity of Current HFpEF Models.

    Circulation research·2026
    Same journal

    Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

    Circulation research·2026
    Same journal

    Meet the First Authors.

    Circulation research·2026
    See all related articles

    Hypertension alters the carotid baroreflex, making it more protective against high blood pressure than low blood pressure. This contrasts with normotensives, where the reflex better defends against hypotension.

    Area of Science:

    • Cardiovascular Physiology
    • Hypertension Research
    • Baroreceptor Function

    Background:

    • Arterial pressure regulation is crucial for cardiovascular health.
    • The carotid sinus baroreceptors play a key role in short-term blood pressure control.
    • Dysfunctional baroreflex contributes to hypertension pathophysiology.

    Purpose of the Study:

    • To investigate the control of arterial pressure by carotid sinus baroreceptors in hypertensive individuals.
    • To compare baroreflex sensitivity in hypertensive and normotensive subjects.
    • To assess the influence of hypertension severity on baroreflex responses.

    Main Methods:

    • Utilized a variable pressure neck chamber to manipulate carotid sinus transmural pressure in hypertensive and normotensive participants.

    Related Experiment Videos

  • Administered phenylephrine and trinitroglycerine to evoke baroreceptor reflexes and assess heart rate changes.
  • Compared responses between hypertensive and normotensive groups.

    • Main Results:

    • Both hypertensive and normotensive subjects showed linear blood pressure responses to altered carotid sinus pressure.
    • Hypertensives exhibited a greater depressor than pressor response, unlike normotensives.
    • Pressor response decreased and depressor response increased with hypertension severity.
    • Carotid baroreceptor control of heart rate also differed between groups.
    • Extracarotid baroreceptor reflexes were significantly diminished in hypertensives.

    Conclusions:

    • The carotid baroreflex in hypertension is biased towards an antihypertensive function.
    • While carotid baroreflex remains active, extracarotid baroreceptor reflexes are impaired in hypertension.
    • These findings highlight altered baroreflex regulation in hypertension, with implications for cardiovascular control.