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Updated: Aug 10, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Neonatal skin and skin care
1Department of Dermatology and Pediatrics, Saint Louis University Health Sciences Center, Missouri, USA.
Insights
Infant skin is delicate and differs significantly from adult skin, increasing risks for newborns. Understanding infant skin development and implementing standardized neonatal nursery care can reduce complications and healthcare costs.
Area of Science:
- Neonatal dermatology
- Pediatric skin physiology
Background:
- Infant skin possesses unique structural and functional characteristics compared to adult skin.
- These differences heighten vulnerability to fluid and electrolyte imbalances, thermal dysregulation, and skin barrier disruption.
- Newborns face elevated risks of percutaneous absorption, infection, and toxicity from topical applications.
Purpose of the Study:
- To review the developmental biology of infant skin.
- To detail current skin care protocols employed in neonatal intensive care units (NICUs).
- To advocate for improved understanding and standardization of neonatal skin care practices.
Main Methods:
- Literature review of infant skin development.
- Analysis of existing neonatal nursery skin care guidelines.
- Synthesis of findings to inform best practices.
Main Results:
- Infant skin's immature barrier function increases susceptibility to damage and absorption.
- Current practices in neonatal nurseries vary, potentially leading to suboptimal outcomes.
- Evidence supports specific emollients and cleansing techniques for preserving the neonatal skin barrier.
Conclusions:
- A comprehensive understanding of infant skin physiology is crucial for neonatal care.
- Standardized, evidence-based skin care protocols in the NICU setting are essential.
- Optimizing neonatal skin care minimizes risks, reduces healthcare costs, and improves patient outcomes.
Abstract:
Infant skin differs from adult skin in several ways. These important differences place infants at increased risk for fluid electrolyte imbalance, thermal instability, skin damage, percutaneous infection, and percutaneous toxicity from topically applied agents. This article includes a review of skin development, as well as the details of current skin care practices in the neonatal nursery. A better understanding of the principles of infant skin care and a more uniform approach to skin care in the neonatal nursery can minimize risks and costs to this special population of patients.
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