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Management of collagen vascular diseases in childhood
1Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania, USA.
Insights
This review covers collagen vascular diseases in children, such as lupus and juvenile rheumatoid arthritis. It details their clinical features and available treatments, including steroid-sparing options.
Area of Science:
- Pediatric Rheumatology
- Autoimmune Diseases
- Connective Tissue Diseases
Background:
- Collagen vascular diseases are uncommon in children but cause significant morbidity.
- Includes conditions like lupus, dermatomyositis, scleroderma, and juvenile rheumatoid arthritis.
- Sjogren's syndrome is a rare possibility in pediatric cases.
Purpose of the Study:
- To describe the clinical features of pediatric collagen vascular diseases.
- To provide an overview of current treatment options.
- To highlight steroid-sparing systemic treatments.
Main Methods:
- Literature review of collagen vascular diseases in pediatric populations.
- Synthesis of clinical manifestations and diagnostic criteria.
- Compilation of established and emerging therapeutic strategies.
Main Results:
- Detailed clinical presentations for various pediatric autoimmune conditions.
- Overview of management strategies, emphasizing systemic therapies.
- Identification of steroid-sparing agents as key treatment components.
Conclusions:
- Pediatric collagen vascular diseases require comprehensive understanding of their varied presentations.
- Current treatment approaches offer effective management, including steroid-sparing options.
- Further research into long-term outcomes and novel therapies is warranted.
Abstract:
Collagen vascular diseases seen in children include systemic, discoid and neonatal lupus, dermatomyositis, scleroderma, juvenile rheumatoid arthritis, and, in rare cases, Sjogren's syndrome. Although these diseases are uncommon in children, when seen, they are associated with significant morbidity. This review describes the clinical features of each condition and provides an overview of treatment options now available. These include numerous systemic treatments which can be used as steroid-sparing agents.