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Experimental intravitreal gentamicin

I G Zachary, R K Forster

    American Journal of Ophthalmology
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Gentamicin intravitreal injections in rabbits showed that doses of 0.1-0.2 mg were well tolerated. Higher doses (0.4 mg+) caused significant ocular toxicity, confirmed by electroretinography and histopathology.

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    Area of Science:

    • Ophthalmology
    • Toxicology
    • Pharmacology

    Background:

    • Intravitreal gentamicin is used for endophthalmitis treatment.
    • Determining the safe dosage of intravitreal gentamicin is crucial to avoid ocular toxicity.

    Purpose of the Study:

    • To evaluate the ocular toxicity of varying intravitreal gentamicin doses in a rabbit model.

    Main Methods:

    • Rabbits received intravitreal injections of gentamicin.
    • Ocular toxicity was assessed using indirect ophthalmoscopy, electroretinography, and histopathology.

    Main Results:

    • Intravitreal gentamicin doses of 0.1 to 0.2 mg were well tolerated.
    • Doses of 0.4 mg or higher resulted in significant ocular toxicity, including electroretinogram extinction, fundus changes, and histopathologic alterations.

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    Conclusions:

    • A threshold dose exists for gentamicin-induced ocular toxicity in rabbits.
    • Careful dose selection is necessary when administering intravitreal gentamicin to minimize retinal damage.