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Related Experiment Videos

Requirements for the electronic crossmatch

W J Judd1

  • 1Department of Pathology, University of Michigan, Ann Arbor, USA. johnjudd@umich.edu

Vox Sanguinis
|August 15, 1998
PubMed
Summary
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Electronic crossmatch (EXM) using laboratory information systems can replace immediate-spin crossmatch for ABO incompatibility detection. Properly programmed software and SOPs ensure safe and efficient blood transfusion processes.

Area of Science:

  • Transfusion Medicine
  • Laboratory Informatics

Background:

  • Laboratory information systems enable new protocols in transfusion services.
  • Immediate-spin crossmatch is a traditional method for detecting ABO incompatibility.

Purpose of the Study:

  • To evaluate the electronic crossmatch (EXM) as a replacement for immediate-spin crossmatch.
  • To outline safety requirements for implementing EXM.

Main Methods:

  • Development of standard operating procedures (SOPs) for EXM.
  • Implementation of computer logic to prevent ABO incompatible blood release.
  • Verification of recipient ABO type and antibody screening.
  • On-site validation of critical system components and data entry mechanisms.

Main Results:

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  • EXM procedures are operational in multiple international facilities.
  • EXM has been successfully implemented in remote locations without laboratory services.
  • EXM effectively detects ABO incompatibility without serological crossmatching.

Conclusions:

  • A combination of programmed software and SOPs ensures safe and efficient EXM.
  • EXM offers a reliable alternative to traditional serological crossmatching for ABO compatibility.