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Growth hormone and aging

A Bartke1

  • 1Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA.

Endocrine
|August 15, 1998
PubMed
Summary
This summary is machine-generated.

Growth hormone (GH) has a controversial role in aging. While high GH may accelerate aging, low GH is linked to longer life, though some aging symptoms improve with GH replacement.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Molecular Biology

Background:

  • Age-related decline in plasma growth hormone (GH) levels is documented.
  • The role of GH in aging control is debated, with conflicting evidence.
  • Physiological changes in the elderly can mimic GH deficiency.

Purpose of the Study:

  • To investigate the controversial role of growth hormone (GH) in aging.
  • To reconcile conflicting data on GH's impact on lifespan and aging phenotypes.
  • To explore the relationship between GH, body size, and longevity.

Main Methods:

  • Examined studies on GH overexpression in transgenic mice.
  • Analyzed data from Ames dwarf mice with hereditary deficiencies in GH, prolactin, and thyrotropin.

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  • Considered clinical observations of GH replacement therapy in the elderly.

    • Main Results:

    • GH overexpression in mice correlated with reduced life expectancy and premature aging.
    • Ames dwarf mice with GH deficiency exhibited significantly longer lifespans.
    • GH replacement therapy in elderly individuals improved symptoms resembling GH deficiency.

    Conclusions:

    • Contradictory effects of GH on aging may depend on dosage and body size.
    • GH's influence on aging is complex, potentially involving dose-response relationships.
    • Further research is needed to elucidate the physiological mechanisms linking GH, body size, and aging.