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Related Experiment Videos

Biopsy bag artifact

T H Niemann1, J G Tranovich, B R De Young

  • 1Department of Pathology, Ohio State University and the Arthur G. James Cancer Hospital and Research Institute, Columbus, USA.

American Journal of Clinical Pathology
|August 15, 1998
PubMed
Summary

A common biopsy bag artifact creates a tic-tac-toe pattern in tissue samples. While usually not affecting diagnosis in gynecological specimens, it can distort small lung and prostate tissues.

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Area of Science:

  • Histopathology
  • Surgical Pathology
  • Biopsy Techniques

Background:

  • Biopsy bags are widely used for tissue processing.
  • Small and delicate tissues are susceptible to processing artifacts.
  • Accurate histopathological interpretation relies on artifact recognition.

Purpose of the Study:

  • To describe a specific tissue artifact.
  • To identify the cause of the artifact.
  • To assess the artifact's prevalence and diagnostic impact.

Main Methods:

  • Microscopic examination of tissue specimens processed with biopsy bags.
  • Observation of characteristic patterns and tissue distortion.
  • Correlation of artifact presence with specimen type.

Main Results:

  • A distinctive artifact, forming a tic-tac-toe pattern, elongated ovals, or serrated contours, was identified.
  • The artifact occurred in 60% of endometrial and 55% of endocervical specimens.
  • Focal distortion occurred in small lung and prostate specimens, potentially impacting diagnosis.

Conclusions:

  • The described artifact is a consequence of using biopsy bags for processing small tissues.
  • The artifact is common in gynecological specimens and usually does not impede diagnosis.
  • Careful evaluation is needed for small lung and prostate specimens due to potential diagnostic compromise.

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