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Protection against gastrointestinal diseases--present facts and future developments

H Kasper1

  • 1University Hospital, Clinic of Internal Medicine, Würzburg, Germany.

International Journal of Food Microbiology
|August 15, 1998
PubMed
Summary
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The intestinal microflora, particularly lactobacilli, plays a key role in gut health. Increasing lactobacilli through diet or supplements shows promise for preventing and treating gastrointestinal issues.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • The intestinal microflora significantly influences human physiological and pathophysiological processes.
  • Key roles include immune modulation, motility regulation, and managing endotoxins.
  • Lactobacilli are recognized for their beneficial effects on gastrointestinal health.

Purpose of the Study:

  • To explore the role of intestinal microflora composition in health and disease.
  • To highlight the therapeutic potential of lactobacilli in gastrointestinal disorders.
  • To review evidence supporting lactobacilli for preventing and treating gut infections and related conditions.

Main Methods:

  • Review of clinical trials and scientific studies on lactobacilli and intestinal microflora.

Related Experiment Videos

  • Analysis of methods to increase lactobacilli proportion (fermented dairy, oligofructose).
  • Evaluation of studies on lactobacilli effects on infections, immunity, motility, and carcinogenesis.

    • Main Results:

    • Lactobacilli consumption, via fermented foods or supplements, can increase their gut proportion.
    • Selected lactobacilli strains demonstrate preventive and therapeutic effects against intestinal infections.
    • Positive impacts observed on immunological parameters, intestinal motility, and inhibition of colon cancer promoting events.

    Conclusions:

    • Lactobacilli hold significant therapeutic potential for various gastrointestinal conditions.
    • Further well-controlled clinical trials are needed to fully elucidate unresolved questions.
    • Modulating the intestinal microflora with lactobacilli offers new avenues for disease prevention and therapy.