Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern adaptation and cross-orientation interactions in the primary visual cortex

M Carandini1, J A Movshon, D Ferster

  • 1Howard Hughes Medical Institute and Center for Neural Science, New York University, NY 10003, USA. matteo@cns.nyu.edu

Neuropharmacology
|August 15, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Restoration of vision after transplantation of photoreceptors.

Nature·2024
Same author

An adaptable, reusable, and light implant for chronic Neuropixels probes.

bioRxiv : the preprint server for biology·2023
Same author

Restoration of vision after transplantation of photoreceptors.

Nature·2012
Same author

Dynamics of the orientation-tuned membrane potential response in cat primary visual cortex.

Nature neuroscience·2001
Same author

Effects of experimental strabismus on the architecture of macaque monkey striate cortex.

The Journal of comparative neurology·2001
Same author

Visual response properties of neurons in the LGN of normally reared and visually deprived macaque monkeys.

Journal of neurophysiology·2001
Same journal

TRPC5 as a Modulator of TRPV1 Signalling in Pathological Pain States.

Neuropharmacology·2026
Same journal

Loss of mGlu<sub>5</sub> receptors from PV inhibitory neurons attenuates sex differences in ethanol and sucrose seeking.

Neuropharmacology·2026
Same journal

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain.

Neuropharmacology·2026
Same journal

Purinergic-cytokine signaling as a regulatory axis in neuroimmune development.

Neuropharmacology·2026
Same journal

Acupuncture Improves Depressive Symptoms and Prefrontal Cortical Function in Mild to Moderate Depressive Disorder: A Randomized Sham-Controlled Trial and fNIRS study.

Neuropharmacology·2026
Same journal

A staged zebrafish-mouse screening strategy for antiseizure compound prioritization.

Neuropharmacology·2026
See all related articles

Pattern adaptation in the visual cortex reduces neural responses. Adaptation to orthogonal orientations has less effect than preferred orientations, suggesting altered interactions between neuronal groups.

Area of Science:

  • Neuroscience
  • Visual Perception
  • Cortical Adaptation

Background:

  • Neuronal responsiveness in the primary visual cortex (V1) decreases with sustained visual stimulation (pattern adaptation).
  • This adaptation is cortical, underlies perceptual after-effects, and shows specificity to the adapting stimulus.
  • Adaptation's specificity suggests it impacts interactions between neuronal groups activated by the stimulus.

Purpose of the Study:

  • To investigate how adaptation affects interactions between neuronal groups tuned to preferred and orthogonal orientations in V1.
  • To determine if adaptation to orthogonal orientations alone influences neuronal responses and interactions differently than adaptation to preferred orientations.

Main Methods:

  • Intracellular recordings of cat V1 neuron membrane potential.

Related Experiment Videos

  • Extracellular recordings of macaque V1 neuron firing rates.
  • Studied adaptation effects using visual patterns with preferred, orthogonal, or both orientations.

    • Main Results:

    • Adaptation to orthogonal orientations alone did not cause the typical hyperpolarization seen with preferred orientation adaptation.
    • Responses were less reduced by orthogonal orientation adaptation compared to preferred orientation adaptation in macaques.
    • Adaptation to stimuli with both orientations modified inter-orientation interactions, increasing cross-orientation suppression in some cells.

    Conclusions:

    • Pattern adaptation can alter interactions between neuronal groups tuned to different orientations in V1.
    • Adaptation to orthogonal orientations has a distinct effect compared to preferred orientations, impacting neuronal communication.
    • These findings suggest adaptation modulates mutual inhibition or excitation between distinct neuronal populations in the visual cortex.