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Effects of experimental hepatic artery embolization on hepatic function

K J Cho, S R Reuter, R Schmidt

AJR. American Journal of Roentgenology

|October 1, 1976

Summary

Hepatic artery embolization in dogs showed temporary liver damage but functional recovery within six weeks. This suggests a potential treatment for patients with severe liver bleeding who cannot undergo surgery.

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Area of Science:

Interventional Radiology
Hepatology
Veterinary Medicine

Background:

Massive hepatic bleeding and hemobilia pose significant clinical challenges.
Surgical interventions like hepatic lobectomy or dearterialization are often required but carry substantial risks.
Non-surgical therapeutic options are needed for patients unsuitable for major surgery.

Purpose of the Study:

To evaluate the effects of hepatic artery embolization on liver function in a canine model.
To assess the safety and functional recovery following hepatic artery embolization.

Main Methods:

The study involved embolizing the hepatic artery of 12 dogs using Gelfoam.
Liver function was monitored serially over six weeks using tests like SGPT, alkaline phosphatase, BSP, and bilirubin.

Main Results:

Eleven out of twelve dogs survived the six-week experimental period.
Hepatic artery embolization induced transient liver damage.
Full liver function recovery was observed by the six-week mark.

Conclusions:

Hepatic artery embolization is a feasible procedure with a high survival rate in this model.
The induced liver damage is reversible, with functional recovery within six weeks.
This technique shows promise as a therapeutic option for managing massive hepatic bleeding or hemobilia in non-surgical candidates.

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