Related Experiment Videos
Lymphocyte signalling: a coordinating role for Vav?
1Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, UK.
Current Biology : CB
|August 26, 1998
Abstract:
Vav1 is a guanine nucleotide exchange factor that selectively activates the Rac1 GTPase and is expressed specifically in haematopoietic cells. Recent work has revealed how Vav1 integrates signals from lymphocyte antigen receptors and costimulatory receptors to control immune function.