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Guar gum-based sustained release diltiazem

S A Altaf1, K Yu, J Parasrampuria

  • 1CIBUS Pharmaceutical, Inc., Menlo Park, California 94026-1226, USA.

Pharmaceutical Research
|August 26, 1998
PubMed
Summary
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Guar gum matrix tablets offer a simple, economical way to achieve sustained release of diltiazem. These formulations demonstrated consistent in vitro dissolution and comparable in vivo pharmacokinetic profiles to a commercial product.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Sustained release formulations are crucial for improving patient compliance and therapeutic efficacy.
  • Diltiazem is a widely used calcium channel blocker for cardiovascular conditions.

Purpose of the Study:

  • To evaluate guar gum as a matrix-forming agent for sustained release diltiazem.
  • To assess the in vitro dissolution and in vivo pharmacokinetic performance of guar gum-based diltiazem tablets.

Main Methods:

  • Preparation and in vitro dissolution testing of guar gum tablet formulations.
  • In vivo pharmacokinetic study in healthy volunteers using a crossover design.
  • Evaluation of diltiazem release under various dissolution conditions and stressed stability.

Main Results:

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  • Diltiazem dissolution from guar gum tablets was largely independent of guar gum source and stir speed.
  • Formulations exhibited good stability under accelerated storage conditions.
  • In vivo studies showed comparable plasma concentration profiles to a reference product (Dilacor XR).

Conclusions:

  • Guar gum is a viable, cost-effective excipient for developing diltiazem sustained release matrix tablets.
  • The developed formulations offer a promising alternative to existing sustained release dosage forms.