Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Glucose Tolerance Test (OGTT): Measuring Glucose Metabolism in Mice02:23

Oral Glucose Tolerance Test (OGTT): Measuring Glucose Metabolism in Mice

11.2K
This video introduces how to perform an oral glucose tolerance test on a laboratory...
11.2K
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

3.2K
Extracellular depletion of fluorescently labeled glucose correlates with glucose uptake and could be used for high-throughput screening of glucose uptake in excised organs and cell cultures.
3.2K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

3.9K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.9K
In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement05:52

In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement

925
This video demonstrates an in vitro assay to indirectly measure intracellular glucose uptake. The assay uses a fluorescently-labeled glucose analog to establish a correlation between extracellular glucose depletion and intracellular glucose...
925
Glucose Transporters01:27

Glucose Transporters

27.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.2K
Assessing Glucose Uptake in the Motor Neurons of Drosophila Larvae with Upregulated Glucose Metabolism04:11

Assessing Glucose Uptake in the Motor Neurons of Drosophila Larvae with Upregulated Glucose Metabolism

429
The video demonstrates a technique for measuring glucose uptake in Drosophila larval motor neurons using a fluorescence resonance energy transfer (FRET)-based intracellular glucose sensor. After dissecting the larvae to expose the ventral nerve cord, the motor neurons are visualized through the fluorescence emitted by the sensor's donor fluorophore. When stimulated with glucose, FRET between the sensor's donor and acceptor fluorophores triggers the emission of fluorescence from the acceptor,...
429

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world weight change among patients treated with glucagon-like peptide-1 receptor agonist, dipeptidyl peptidase-4 inhibitor and sulfonylureas for type 2 diabetes and the influence of medication adherence.

Obesity science & practice·2017
Same author

Evaluation of immunogenicity of LY2963016 insulin glargine compared with Lantus® insulin glargine in patients with type 1 or type 2 diabetes mellitus.

Diabetes, obesity & metabolism·2015
Same author

Identifying the worries and concerns about hypoglycemia in adults with type 2 diabetes.

Journal of diabetes and its complications·2015
Same author

What is so tough about self-monitoring of blood glucose? Perceived obstacles among patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

Pramlintide in the treatment of diabetes.

International journal of clinical practice·2006
Same author

Benchmark data from the literature for evaluation of new glucose sensing technologies.

Diabetes technology & therapeutics·2002

Related Experiment Video

Updated: Jan 20, 2026

Bergmeyer Glucose Quantification for Microbiological Samples
07:23

Bergmeyer Glucose Quantification for Microbiological Samples

Published on: January 17, 2025

1.1K

Importance of glucose control

S V Edelman1

  • 1Department of Medicine, University of California, San Diego, USA.

The Medical Clinics of North America
|August 26, 1998
PubMed
Summary

Achieving near-normal glycemic control, measured by glycosylated hemoglobin, is crucial for reducing diabetes complications. Individualized treatment plans are essential for all patients with diabetes to prevent long-term health issues.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Public Health

Background:

  • Glycemic control significantly reduces microvascular complications in type 1 diabetes.
  • Evidence suggests benefits for microvascular complications in type 2 diabetes, though data is less robust.
  • The collective evidence strongly supports glucose control for both microvascular and macrovascular health in diabetes.

Purpose of the Study:

  • To evaluate the importance of glycemic control in preventing microvascular and macrovascular complications in type 1 and type 2 diabetes.
  • To review the literature on the relationship between glycemic control, hyperinsulinemia, and atherosclerosis.
  • To establish a standard of care for glycemic management in diabetes.

Main Methods:

  • Review of prospective studies and interventional trials on glycemic control and diabetes complications.

More Related Videos

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

3.2K
In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement
05:52

In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement

925

Related Experiment Videos

Last Updated: Jan 20, 2026

Bergmeyer Glucose Quantification for Microbiological Samples
07:23

Bergmeyer Glucose Quantification for Microbiological Samples

Published on: January 17, 2025

1.1K
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

3.2K
In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement
05:52

In Vitro Glucose Depletion Assay: A Fluorescence-Based Method to Quantify Cellular Glucose Uptake via Extracellular Glucose Depletion Measurement

925
  • Analysis of literature evaluating the link between glycemic control and macrovascular disease.
  • Assessment of the relationship between hyperinsulinemia and atherosclerosis in diabetes.

    • Main Results:

    • Strong evidence demonstrates that improved glycemic control reduces microvascular complications in type 1 diabetes.
    • Collective data indicate that good glycemic control is important for reducing both microvascular and macrovascular complications in type 1 and type 2 diabetes.
    • No negative studies on the benefits of lowering glycosylated hemoglobin have been reported.

    Conclusions:

    • The primary glycemic goal for most patients with diabetes should be lowering glycosylated hemoglobin to less than 2 percentage points above the normal upper limit.
    • Individualized, tailored treatment regimens are necessary, and intensive glycemic control aims for normal or near-normal glycemic values.
    • All patients with diabetes require education and access to individualized treatment plans for normalizing glycemic control, which should be the standard of care.