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Paget's disease of bone (osteitis deformans)

M A Ankrom1, J R Shapiro

  • 1Department of Medicine, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.

Journal of the American Geriatrics Society
|August 26, 1998
PubMed
Summary

Paget

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Area of Science:

  • Geriatric Medicine
  • Bone Metabolism
  • Rheumatology

Background:

  • Paget's disease of bone is a prevalent skeletal disorder in the elderly, second only to osteoporosis.
  • It significantly impacts geriatric patients, causing chronic pain, deformities, hearing loss, and reduced mobility.
  • Early diagnosis and treatment are crucial to prevent debilitating complications.

Purpose of the Study:

  • To review the clinical manifestations of Paget's disease in older adults.
  • To discuss effective diagnostic and therapeutic strategies for managing Paget's disease in geriatrics.
  • To highlight the importance of an aggressive approach to treatment for improved patient outcomes.

Main Methods:

  • Literature review focusing on Paget's disease in geriatric populations.
  • Analysis of current diagnostic methods for assessing disease activity.
  • Evaluation of therapeutic options, including salmon calcitonin and bisphosphonates.

Main Results:

  • Paget's disease presents with diverse symptoms in the elderly, affecting function and mobility.
  • Newer diagnostic tests and effective treatments, such as nasal salmon calcitonin and third-generation bisphosphonates, are available.
  • Treatment can often reverse disease progression and alleviate symptoms.

Conclusions:

  • An aggressive diagnostic and treatment strategy is recommended for Paget's disease in older patients.
  • The primary goals of management are pain relief, improved mobility, and prevention of complications.
  • Effective therapies can significantly improve the quality of life for geriatric individuals with Paget's disease.

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