Related Experiment Videos
Peripheral blood CD34+ cell count reliably predicts autograft yield
P Chapple1, H M Prince, M Quinn
1Department of Pathology, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
Bone Marrow Transplantation
|August 26, 1998
Summary
Predicting peripheral blood progenitor cell (PBPC) autograft CD34+ cell content is crucial for optimizing collection timing. A peripheral blood CD34+ cell count exceeding 5.0 x 10(6)/l reliably predicts successful PBPC autograft collection.
Area of Science:
- Hematology
- Oncology
- Transplant Medicine
Background:
- Optimizing peripheral blood progenitor cell (PBPC) collection requires a reliable predictor of autograft CD34+ cell content.
- Accurate timing of PBPC collection is essential for successful autologous transplantation.
Purpose of the Study:
- To prospectively evaluate the correlation between peripheral blood (PB) CD34+ cell count and PBPC autograft parameters.
- To establish a predictive threshold for PB CD34+ cell count to ensure adequate autograft yield.
Main Methods:
- Prospective analysis of 59 patients undergoing PBPC autograft collection.
- Measurement of PB CD34+ cell counts and correlation with autograft CD34+ cell, CFU-GM, and MNC content.
Main Results:
- A strong linear correlation (r=0.8477) was found between PB CD34+ cells/l and autograft CD34+ cells/kg.
- PB CD34+ cell count exceeding 5.0 x 10(6)/l reliably predicted achieving the target of 0.5 x 10(6) CD34+ cells/kg.
Conclusions:
- Peripheral blood CD34+ cell count is a strong predictor of autograft CD34+ cell content.
- A PB CD34+ cell count threshold of 5.0 x 10(6)/l can guide optimal PBPC collection timing for autologous transplantation.