Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Household aggregation of pulmonary function and chronic bronchitis

I B Tager, B Rosner, P V Tishler

    The American Review of Respiratory Disease
    |September 1, 1976
    PubMed
    Summary

    Chronic bronchitis and lung function, specifically 1-sec forced expiratory volume, tend to aggregate within families. This familial aggregation suggests a potential genetic component influencing respiratory health outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Simultaneous mapping of the ultrafast time and fluence dependence of the laser-induced insulator-to-metal transition in magnetite.

    Structural dynamics (Melville, N.Y.)·2025
    Same author

    Maternal rotating night shift work before pregnancy and offspring stress markers.

    Physiology & behavior·2019
    Same author

    Rotating night shift work and menopausal age.

    Human reproduction (Oxford, England)·2019
    Same author

    Towards X-ray transient grating spectroscopy.

    Optics letters·2019
    Same author

    Different menopausal hormone regimens and risk of breast cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2018
    Same author

    Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts.

    European journal of clinical nutrition·2016

    Area of Science:

    • Pulmonary Medicine
    • Environmental Health
    • Genetics

    Background:

    • Chronic respiratory diseases pose a significant public health burden.
    • Understanding the factors contributing to disease aggregation within households is crucial for prevention strategies.
    • Familial aggregation studies can help elucidate the interplay of genetic and environmental influences on health.

    Purpose of the Study:

    • To investigate the intrafamilial aggregation of chronic bronchitis.
    • To examine the familial aggregation of lung function, specifically 1-sec forced expiratory volume (FEV1).
    • To explore the influence of parental smoking on lung function correlations within families.

    Main Methods:

    • A cross-sectional study involving 148 households in an urban community.

    Related Experiment Videos

  • Home-based screening using a modified British Medical Research Council (MRC) respiratory questionnaire.
  • Spirometry measurements using a portable spirometer to assess lung function (FEV1).

    • Main Results:

    • A significant tendency for chronic bronchitis to aggregate within households was observed.
    • Significant aggregation was found for 1-sec forced expiratory volume (FEV1), both as a percentage of predicted value and as a calculated score.
    • FEV1 showed significant correlation between siblings, with weaker correlations between spouses.
    • Maternal smoking confounded the mother-child FEV1 correlation, particularly with male offspring.
    • Paternal FEV1 significantly correlated with offspring FEV1, especially female offspring, independent of smoking.

    Conclusions:

    • Chronic bronchitis and FEV1 exhibit familial aggregation, suggesting a potential genetic predisposition.
    • The influence of shared household environments and parental behaviors (e.g., smoking) impacts intrafamilial lung function correlations.
    • Further research is warranted to disentangle the genetic and environmental contributions to respiratory health within families.