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Inhaled atropine sulfate: dose response characteristics
The American Review of Respiratory Disease
|September 1, 1976
Summary
Inhaled atropine sulfate effectively dilates airways in children with asthma, with peak effects seen one hour post-inhalation. Optimal bronchodilation occurs at higher doses, suggesting previous efficacy variations may stem from under-dosing.
Area of Science:
- Pulmonary Medicine
- Pediatric Pulmonology
- Pharmacology
Background:
- Inhaled atropine sulfate's role as a bronchodilator in humans is established, but optimal dosage and efficacy require further investigation.
- Chronic perennial asthma in children necessitates effective bronchodilator therapies.
Purpose of the Study:
- To determine the dose-response characteristics of inhaled atropine sulfate in children with chronic perennial asthma.
- To identify the optimal dosage and duration of action for inhaled atropine sulfate as a bronchodilator.
Main Methods:
- Twenty children with chronic perennial asthma participated in the study.
- Maximal expiratory flow-volume curves were used to assess bronchodilator effects.
- Incremental doses of inhaled atropine sulfate (0.005 to 0.1 mg/kg) were administered.
Main Results:
- A peak bronchodilating effect was observed one hour after inhalation, with significant effects lasting up to 300 minutes depending on the dose.
- A dose-response plateau was reached between 0.05 and 0.1 mg/kg.
- Inhaled atropine sulfate significantly increased specific conductance and decreased the residual volume to total lung capacity ratio.
Conclusions:
- Inhaled atropine sulfate is an effective bronchodilator for children with severe asthma.
- Variations in reported efficacy may be attributed to inadequate dosing.
- Further research into optimal dosing strategies is warranted.