Progesterone challenge test for evaluation of endometrial hyperplasia in postmenopausal women

One hundred and ninety asymptomatic postmenopausal women were examined by transvaginal sonography. Progesterone challenge test (PCT) was performed in 46 of the women with measured endometrial thickness equal to or greater than 6 mm. PCT positive were 32 of these women and they underwent curettage. Endometrial hyperplasia was detected in 18 women and in 2 of the atypical hyperplasia was verified. The authors conclude that PCT is a convenient and safe screening method for women at high risk for endometrial cancer.