Related Experiment Video

Updated: Aug 14, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

[3 cases of bone marrow necrosis in acute leukemia]

J L Montemayor-Montoya1, R E De León-Cantú, D Gómez-Almaguer

  • 1Departamento de Medicina Interna, Hospital Universitario de la UANL, Monterrey, N.L., México.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|July 1, 1997
PubMed

Insights

Bone marrow necrosis (BMN), a condition often diagnosed postmortem, can occur in patients with acute leukemia. Antemortem diagnosis is challenging but possible, offering a chance for early intervention and improved outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Bone marrow necrosis (BMN) is a rare clinicopathological entity.
  • It is frequently associated with hematological malignancies, particularly acute leukemia.
  • Diagnosis is typically made during postmortem examination.

Observation:

  • This report details three cases of BMN diagnosed antemortem.
  • Two patients had acute myeloid leukemia (AML), and one had acute lymphocytic leukemia (ALL).
  • Two patients succumbed to intracranial hemorrhage; however, one AML patient achieved complete remission and long-term survival.

Findings:

  • Antemortem diagnosis of BMN in leukemia patients is feasible, though challenging.
  • BMN is not invariably linked to a fatal outcome.
  • Chemotherapy and supportive care may lead to recovery.

Implications:

  • Highlights the possibility of antemortem diagnosis for BMN.
  • Suggests that early diagnosis and aggressive supportive management can improve prognosis.
  • Underscores the need for increased awareness among clinicians regarding BMN in leukemia patients.

More Related Videos

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...