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Related Experiment Videos

Pediatric AIDS prognosis using somatic growth velocity

V J Carey1, F H Yong, L M Frenkel

  • 1Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA.

AIDS (London, England)
|August 26, 1998
PubMed
Summary

Growth velocity deficits are common in children with human immunodeficiency virus (HIV) infection. Slower growth predicts a higher risk of death in pediatric AIDS patients, offering a simple prognostic tool.

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Area of Science:

  • Pediatric infectious diseases
  • Growth and development in immunocompromised children
  • Biostatistics in clinical trials

Background:

  • Children with human immunodeficiency virus (HIV) infection often experience impaired somatic growth.
  • Establishing normative growth velocity data is crucial for monitoring disease progression and treatment efficacy.

Purpose of the Study:

  • To establish age-specific growth velocity norms for HIV-infected children.
  • To evaluate the prognostic value of these growth velocity norms in predicting outcomes.

Main Methods:

  • Pooled data from 1338 HIV-infected children (3 months to 15 years) across four US clinical trials.
  • Calculated growth velocity distributions using statistical smoothing and quantile regression.
  • Derived age- and sex-corrected z-scores for growth velocity.

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Main Results:

  • HIV-infected children exhibited significant deficits in height and weight velocity compared to reference standards.
  • Approximately 33% of height and 20% of weight velocities fell below the third percentile, indicating growth failure.
  • Both height and weight velocity significantly predicted mortality risk in children with AIDS, independent of other factors.

Conclusions:

  • Normalized growth velocities serve as informative and cost-effective prognostic markers for pediatric AIDS.
  • The presented growth velocity distributions can benchmark new therapeutic strategies against established antiretroviral treatments.