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Related Experiment Videos

Infective endocarditis-induced crescentic glomerulonephritis dramatically improved by plasmapheresis

S Daimon1, Y Mizuno, S Fujii

  • 1Department of Internal Medicine, Maizuru Kyosai Hospital, Kyoto, Japan. 3kens@med.kanazawa-u.ac.jp

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|August 26, 1998
PubMed
Summary

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Plasmapheresis may effectively treat crescentic glomerulonephritis (GN) caused by infective endocarditis. This treatment, alongside antibiotics and defect repair, improved a patient with Streptococcus viridans endocarditis and GN.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Cardiology

Background:

  • Infective endocarditis (IE) can lead to severe renal complications, including crescentic glomerulonephritis (GN).
  • Ventricular septal defect (VSD) is a predisposing factor for IE.
  • Crescentic GN presents with acute renal insufficiency, anemia, and purpura.

Observation:

  • A 50-year-old woman with a history of VSD developed IE with Streptococcus viridans.
  • The patient presented with purpura, anemia, fever, and acute renal insufficiency.
  • Echocardiography and renal biopsy confirmed IE-induced crescentic GN.

Findings:

  • Standard antibiotic therapy was ineffective for the GN.
  • Plasmapheresis led to dramatic improvement in fever and renal function.

Related Experiment Videos

  • Successful VSD closure was performed after clinical stabilization.

    • Implications:

    • Plasmapheresis may be a beneficial adjunctive therapy for infective endocarditis-induced crescentic GN.
    • Early intervention with plasmapheresis can improve renal outcomes in IE-related GN.
    • This case highlights the importance of addressing underlying cardiac defects in IE management.