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Calciuria, magnesiuria and creatininuria--relation to age
A Simecková1, V Zamrazil, J Cerovská
1Institute of Endocrinology, Prague, Czech Republic.
Insights
Urinary calcium and magnesium levels vary significantly with age. This study in 2715 individuals found distinct concentration patterns for these minerals and their ratios with creatinine across different life stages.
Area of Science:
- Clinical Biochemistry
- Pediatric Nephrology
- Geriatric Medicine
Background:
- Urinary mineral excretion is crucial for maintaining homeostasis.
- Age-related changes in renal function can impact mineral balance.
- Understanding normative values across the lifespan is essential for clinical interpretation.
Purpose of the Study:
- To determine age-specific reference ranges for urinary calcium, magnesium, and creatinine.
- To investigate the influence of age on urinary calcium/creatinine and magnesium/creatinine ratios.
- To establish normative data for a diverse population.
Main Methods:
- Analysis of 2715 first morning urine samples.
- Inclusion of participants across a wide age spectrum (1-93 years).
- Random selection from diverse regions within the Czech Republic.
Main Results:
- Urinary calcium concentration was lowest in the youngest and oldest age groups, peaking in adults aged 18-35.
- Urinary magnesium concentration peaked in 4-year-old children, declining thereafter.
- Urinary calcium/creatinine and magnesium/creatinine ratios were highest in the 1-4 year age group.
Conclusions:
- Age significantly influences urinary calcium, magnesium, and their ratios with creatinine.
- Distinct age-dependent patterns exist for urinary mineral excretion.
- Reference ranges for these analytes should consider age-specific variations.
Abstract:
We assessed the concentration of calcium, magnesium and creatinine in 2715 samples of the first morning urine. The investigation comprised the following age groups: children one, two, four, six, ten and thirteen years old, and groups of adults aged 18-35, 36-49, 50-65, 66-75, 76-85 and 86-93 years. The choice was made by random selection of participants of both sexes from diverse regions of the Czech Republic. We found the age to have a marked influence on the value of calcium, magnesium and creatinine, including urinary concentration ratios of calcium/creatinine and magnesium/creatinine. The urinary calcium concentration was low both in the early and advanced age groups, while it reached peak values in subjects 18-35 years old. The urinary magnesium concentration was also age-dependent, with a maximum in children aged 4 years, and a subsequent decline with advancing age. The value of the ratio urinary calcium/creatinine and urinary magnesium/creatinine was highest in the youngest age group (1-4 years).