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Calciuria, magnesiuria and creatininuria--relation to age
A Simecková1, V Zamrazil, J Cerovská
1Institute of Endocrinology, Prague, Czech Republic.
Physiological Research
|August 26, 1998
Summary
Urinary calcium and magnesium levels vary significantly with age. This study in 2715 individuals found distinct concentration patterns for these minerals and their ratios with creatinine across different life stages.
Area of Science:
- Clinical Biochemistry
- Pediatric Nephrology
- Geriatric Medicine
Background:
- Urinary mineral excretion is crucial for maintaining homeostasis.
- Age-related changes in renal function can impact mineral balance.
- Understanding normative values across the lifespan is essential for clinical interpretation.
Purpose of the Study:
- To determine age-specific reference ranges for urinary calcium, magnesium, and creatinine.
- To investigate the influence of age on urinary calcium/creatinine and magnesium/creatinine ratios.
- To establish normative data for a diverse population.
Main Methods:
- Analysis of 2715 first morning urine samples.
- Inclusion of participants across a wide age spectrum (1-93 years).
- Random selection from diverse regions within the Czech Republic.
Main Results:
- Urinary calcium concentration was lowest in the youngest and oldest age groups, peaking in adults aged 18-35.
- Urinary magnesium concentration peaked in 4-year-old children, declining thereafter.
- Urinary calcium/creatinine and magnesium/creatinine ratios were highest in the 1-4 year age group.
Conclusions:
- Age significantly influences urinary calcium, magnesium, and their ratios with creatinine.
- Distinct age-dependent patterns exist for urinary mineral excretion.
- Reference ranges for these analytes should consider age-specific variations.