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Human herpesvirus type 8 and Kaposi's sarcoma
R A Weiss1, D Whitby, S Talbot
1Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
Journal of the National Cancer Institute. Monographs
|August 26, 1998
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to Kaposi's sarcoma and related conditions. This virus encodes proteins that promote cell growth and survival, and may have anti-HIV and angiogenic effects.
Area of Science:
- Virology
- Oncology
- Immunology
Background:
- Kaposi's sarcoma-associated herpesvirus, also known as human herpesvirus type 8 (HHV-8), is implicated in Kaposi's sarcoma (KS), primary effusion lymphomas, and Castleman's disease.
- HHV-8 is found in endothelial and spindle cells within KS tissues.
- Serologic studies indicate HHV-8 is more prevalent in individuals at risk for KS and less widespread than other human herpesviruses.
Purpose of the Study:
- To summarize the role of HHV-8 in various diseases.
- To highlight the viral proteins encoded by HHV-8 and their potential functions.
- To discuss the epidemiological distribution of HHV-8.
Main Methods:
- Literature review of studies on HHV-8 and associated diseases.
- Analysis of HHV-8's genetic material and encoded proteins.
- Review of serologic data regarding HHV-8 prevalence.
Main Results:
- HHV-8 is a consistent finding in Kaposi's sarcoma and related lymphoproliferative disorders.
- The virus encodes proteins homologous to cyclins, G-coupled receptors, Bcl-2, IL-6, and FLIP, suggesting roles in cellular growth and apoptosis.
- HHV-8 also produces macrophage inflammatory-like proteins with potential anti-HIV and angiogenic activities.
Conclusions:
- HHV-8 plays a critical role in the pathogenesis of KS and related conditions.
- The viral proteins encoded by HHV-8 contribute to cellular dysregulation, including proliferation and survival.
- Further research into HHV-8's functions may reveal therapeutic targets for associated diseases.