Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells in the testis

D G de Rooij1

  • 1Department of Cell Biology, Utrecht University, The Netherlands. d.g.derooij@med.ruu.nl

International Journal of Experimental Pathology
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

This review covers spermatogonial stem cell kinetics and regulation during spermatogenesis in mammals. It highlights the vulnerable differentiation stage and introduces stem cell transplantation as a key research tool.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.

Human reproduction (Oxford, England)·2013
Same author

Functional relationship between obesity and male reproduction: from humans to animal models.

Human reproduction update·2011
Same author

Embryonic stem cell-like cells derived from adult human testis.

Human reproduction (Oxford, England)·2009
Same author

Phosphoprotein enriched in astrocytes-15 is expressed in mouse testis and protects spermatocytes from apoptosis.

Reproduction (Cambridge, England)·2007
Same author

Asthenoteratozoospermia in mice lacking testis expressed gene 18 (Tex18).

Molecular human reproduction·2007
Same author

Expression of stress inducible protein 1 (Stip1) in the mouse testis.

Molecular reproduction and development·2006
Same journal

Exosomal miR-221-3p derived from bone marrow mesenchymal stem cells alleviates endoplasmic reticulum stress-mediated apoptosis in nucleus pulposus cells via the Nrf2/HO-1 signalling pathway.

International journal of experimental pathology·2025
Same journal

Effect of pulmonary arterial hypertension on the morphology and antioxidant defence of the ventral prostate of sedentary and exercised rats.

International journal of experimental pathology·2025
Same journal

Correction to 'The Energy Density of Laser Light Differentially Modulates the Skin Morphological Reorganization in a Murine Model of Healing by Secondary Intention'.

International journal of experimental pathology·2025
Same journal

Roles of long non-coding RNAs in oesophageal cancer pathogenesis.

International journal of experimental pathology·2025
Same journal

Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism.

International journal of experimental pathology·2025
Same journal

Molecular epidemiology of Epstein-Barr virus in gastric cancer patients compared to healthy control group in Shiraz, Iran.

International journal of experimental pathology·2025
See all related articles

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Spermatogenesis involves the development of germ cells into mature sperm.
  • Spermatogonial stem cells are crucial for maintaining continuous sperm production in adult mammals.
  • Understanding the transition from fetal germ cells to adult spermatogonia is key to comprehending spermatogenesis initiation.

Purpose of the Study:

  • To review the origin and development of the mammalian spermatogenic cell lineage.
  • To discuss spermatogonial kinetics and the regulation of proliferation and differentiation.
  • To present a hypothesis for the transition from fetal gonocytes to adult spermatogonia.

Main Methods:

  • Literature review of spermatogenesis, spermatogonial kinetics, and stem cell regulation.

Related Experiment Videos

  • Discussion of models for studying spermatogonial differentiation.
  • Description of the spermatogonial stem cell transplantation technique.

    • Main Results:

    • The differentiation of undifferentiated into differentiating spermatogonia is a vulnerable stage in spermatogenesis.
    • Research into the molecular regulation of spermatogonial processes is in its early stages.
    • Spermatogonial stem cell transplantation is a valuable new research tool.

    Conclusions:

    • Current models for studying spermatogonial differentiation are described.
    • The molecular basis of spermatogonial regulation requires further investigation.
    • There are currently no adequate animal or in vitro models for studying human germ cell tumors experimentally.