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Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations
A Segura Carretero1, C Cruces Blanco, B Cañabate Díaz
1Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Spain.
Abstract:
A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TINO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml-1 and a relative standard deviation of 3.74% at the 500 ng ml-1 level. The method was applied to the analysis of pharmaceutical preparations.
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