Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catalyst discovery through combinatorial chemistry

A H Hoveyda1

  • 1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.

Chemistry & Biology
|August 26, 1998
PubMed
Summary

Combinatorial chemistry and high-throughput screening efficiently identify potent small-molecule chiral catalysts. Infrared thermography rapidly pinpoints the most active catalysts for chemical synthesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanism of enantioselective Ti-catalyzed Strecker reaction: peptide-based metal complexes as bifunctional catalysts.

Journal of the American Chemical Society·2001
Same author

Three-component catalytic asymmetric synthesis of aliphatic amines.

Journal of the American Chemical Society·2001
Same author

Catalytic asymmetric ring-opening metathesis/cross metathesis (AROM/CM) reactions. Mechanism and application to enantioselective synthesis of functionalized cyclopentanes.

Journal of the American Chemical Society·2001
Same author

Modular peptide-based phosphine ligands in asymmetric catalysis: efficient and enantioselective Cu-catalyzed conjugate additions to five-, six-, and seven-membered cyclic enones.

Journal of the American Chemical Society·2001
Same author

Enantioselective synthesis of arylamines through Zr-catalyzed addition of dialkylzincs to imines. Reaction development by screening of parallel libraries.

Journal of the American Chemical Society·2001
Same author

Zr-catalyzed electrophilic carbomagnesation of aryl olefins. Mechanism-based control of Zr-Mg ligand exchange.

Organic letters·2001

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Chemical Engineering

Background:

  • Small-molecule chiral catalysts are crucial for asymmetric synthesis.
  • Identifying effective catalysts often requires extensive screening.
  • High-throughput methods accelerate catalyst discovery.

Purpose of the Study:

  • To explore the use of combinatorial chemistry and high-throughput strategies for identifying effective small-molecule chiral catalysts.
  • To evaluate infrared thermography as a method for rapidly assessing catalyst activity.

Main Methods:

  • Combinatorial synthesis of small-molecule libraries.
  • High-throughput screening assays.
  • Infrared thermography for real-time activity monitoring.

Main Results:

  • Successful identification of several highly active small-molecule chiral catalysts.
  • Demonstration of infrared thermography's efficacy in ranking catalyst performance.
  • Correlation between thermographic data and catalytic efficiency.

Conclusions:

  • Combinatorial chemistry coupled with high-throughput screening is a powerful approach for discovering novel chiral catalysts.
  • Infrared thermography offers a rapid and effective tool for catalyst screening and optimization in chemical research.

Related Experiment Videos