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Related Experiment Videos

Percutaneous adrenal suppression with topically applied corticosteroids

J C Gruenberg, G R Mikhail

    Archives of Surgery (Chicago, Ill. : 1960)
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Topical corticosteroids like triamcinolone acetonide can suppress adrenal function, leading to decreased cortisol levels. This effect is reversible and indicates suppression, not insufficiency, in most cases.

    Area of Science:

    • Endocrinology
    • Dermatology

    Background:

    • Topical corticosteroids, particularly synthetic fluorinated derivatives of cortisone, are widely used for inflammatory skin conditions.
    • These potent compounds can be absorbed through the skin and potentially exert systemic effects.

    Observation:

    • A case study involving extensive topical application of triamcinolone acetonide for atopic dermatitis is presented.
    • A significant decrease in plasma cortisol levels was observed in the patient.

    Findings:

    • The observed decrease in plasma cortisol was attributed to adrenal suppression, not adrenal insufficiency.
    • A positive response to a cosyntropin injection test confirmed the adrenal glands' ability to function when stimulated.

    Implications:

    Related Experiment Videos

  • Extensive topical corticosteroid use can lead to reversible adrenal suppression.
  • Patients with a history of recent, widespread topical corticosteroid use require careful monitoring for potential adrenal insufficiency, especially perioperatively.