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[Effect of zinc deficiency on the digestibility and utilization of nutrients]
Abstract:
Weaned male rats were used in a metabolic trial to investigate the digestibility of dry matter, crude protein, ash and energy, the energy and N balances and the rates of zinc absorption and zinc retention under conditions of zinc deficiency. 2X8 experimental animals were kept in separate metabolism cages for 6 periods each lasting 5 days. The animals received a semisynthetic zinc-deficient diet (casein + starch + sucrose) containing only 1.0 mg Zn per kg of dry matter (zinc-deficient group fed ad libitum) or plus 49 mg Zn per kg of dry matter (pair-fed control group). The mean intake of dry matter was 2-3 g per day/animal. 2.9 g of food were necessary to produce 1 g of weight increase in the deficient animals and 1.4 g in the controls. The rate of apparent zinc absorption was always clearly negative in the Zn-deficient group. In the control group apparent zinc absorption decreased from 60% to 27% in the course of the trial while zinc retention decreased from 51% to 10%. During zinc deficiency the rates of both faecal and absolute renal Zn excretion were found to be greatly reduced. The proportion of renal zinc excretion relative to total excretion averaged 60% in the experimental group as compared to 17% in the controls. No significant differences were found in the digestibility data of gross energy. Nutrient digestibility (%) was significantly reduced under conditions of Zn deficiency (data for the control group given in brackets): 92,6 (94.0) for dry matter; 93,2 (94.1) for organic matter; 93.3 (96.2) for crude protein and 76.6 (90.8) for crude ash. Similarly, N retention data, in Zn-deficient animals, declined from 30.5% to 14.7%, and metabolizable energy decreased from 88.7% to 85.6%. The differences obtained are not sufficient, however, to account for the clearly increased food requirements observed in zinc-deficient animals. Thus, considerable disturbances have to be assumed to occur in the processes of intermediary nutrient utilization.