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[Meta-analysis of epidemiologic studies]

M Blettner1, W Sauerbrei

  • 1Deutsches Krebsforschungszentrum, Abteilung Epidemiologie, Heidelberg.

Medizinische Klinik (Munich, Germany : 1983)
|August 26, 1998
PubMed
Summary

Meta-analysis can quantify weak associations when risk assessment is difficult. Individual patient data meta-analysis offers more reliable results than published data, despite higher costs.

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Area of Science:

  • Epidemiology
  • Biostatistics

Context:

  • Meta-analysis is crucial for risk assessment when epidemiological data is limited.
  • Quantifying weak associations is a primary goal of meta-analysis.
  • Methodological differences exist between meta-analysis of published data and individual patient records.

Purpose:

  • To describe methodological issues in meta-analysis.
  • To highlight the distinction between meta-analysis using published data versus individual patient records.
  • To exemplify these issues using studies on oral contraceptives and breast cancer.

Summary:

  • This paper examines the methodological challenges in meta-analysis.
  • It contrasts meta-analysis derived from published studies with that using individual patient data.
  • Limitations inherent in meta-analysis of published data are detailed.

Impact:

  • Individual patient data meta-analysis yields more reliable findings.
  • While potentially more resource-intensive, individual data meta-analysis enhances result accuracy.
  • Understanding these methodological nuances improves the interpretation of epidemiological risk assessments.

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